Skip to main content

These positions are currently available at the Heart Research Institute for UK citizens.

  • Postdoctoral Researcher - Microvascular Physiology: Find out more and apply below.
  • Postdoctoral Researcher - Atherosclerosis and Vascular Remodelling: Find out more and apply here.

Postdoctoral Researcher - Microvascular Physiology

An exciting opportunity exists to carry out two years of fully funded post-doctoral research investigating the impact of septic shock on microvascular function.

This position is split across the laboratories of Dr Chris Stanley at the Heart Research Institute (HRI), University of Sydney, Australia and Dr’s Adam Greenstein and Harry Pritchard’s small artery group at the University of Manchester, UK. The successful candidate will spend a year working in Sydney, Australia and then a year in Manchester, UK. The post is funded from a grant from the UK branch of the HRI and as a condition of funding is open to UK citizens only. The universities of Manchester and Sydney will assist in travel and visa organisation for the successful applicant.

HRI is a centre of excellence in cardiovascular medical research, affiliated with the Royal Prince Alfred Hospital and the University of Sydney located in Newtown, Sydney. The primary focus of the Institute is to make fundamental discoveries in cardiovascular research that will advance the detection, prevention, and treatment of cardiovascular disease.

POSITION DETAILS

The research follows on from the recent work of Dr Stanley’s Nature 2019. 566; p548 and Nat Commun 2021. 12; p6626 and will use cutting edge vascular physiology techniques as used in Dr’s Greenstein and Pritchard’s lab’s (Circulation Research 2021. 128: p1279, PNAS 2020. 116; p21874 and Hypertension 2020. 75; p539). The appointed person will work with microvascular arteries taken from models of septic shock to understand how disease pathology changes membrane potential and calcium signalling. Such changes are hypothesised to drive disease-associated sustained vasodilation, and fatal hypotension. This research will utilise myography, electrophysiology, calcium imaging, and a range of microscopy techniques. As well as leading a project, the successful post-doctoral researcher will also be given fantastic opportunities to collaborate on other projects within the lab and/or within the host institute.

Essential criteria – you will have:

  • Expertise in microvascular physiology
  • Technical knowledge of small artery research techniques, specifically myography
  • A PhD in biological, physiological, or pharmacological fields
  • Previously performed confocal and other high-end microscopy
  • A history of basic & translational research with experience of high impact publications
  • Good interpersonal, written, and oral communication skills
  • Skills in calcium imaging and/or electrophysiology
  • Experience with small animal models of disease
  • High levels of motivation and a capacity for independent work

Desirable criteria – you will have:

  • A good understanding of redox biochemistry
  • Prior knowledge of sepsis and septic shock
  • Experience in molecular biology techniques (such as cell culture, western blot and recombinant DNA techniques)
  • Analytical biochemistry techniques HPLC, mass spectrometry, omics

Position requirements:

In addition to the listed criteria, the successful candidate will be expected to contribute to the research program by performing a range of research-related tasks which may include the following:

  • Assist in the conduct and design of experiments
  • Assist in the general supervision of students in the laboratory
  • Assist in the preparation of documents (for grant applications, research/conference papers, ethics applications)
  • Provide administrative and animal management support for research projects and programs including the maintenance of electronic databases and records
  • Lab management including standard maintenance of equipment, and maintaining occupational health and safety standards particular lab equipment and materials, including waste disposal and ordering supplies
  • Maintain occupational health and safety standards

The position is full time; flexible working arrangements may be negotiated. The appointment period is initially for 2 years with the possibility of renewal. You will be employed by the Heart Research Institute, Sydney, Australia and the University of Manchester, UK.

Eligibility:

To apply for this position, in accordance with the funding agreement, you must be a UK citizen.

Remuneration:

This post is offered with a competitive starting salary, plus superannuation contributions and generous not-for-profit salary packaging options.

How to apply:

You can apply via the form at the bottom of this page. Your application should include:

  • A cover letter and detailed curriculum vitae (CV)
  • The names and full contact details of three professional referees (including email addresses)

Further information:

Please contact Dr Chris Stanley christopher.stanley@hri.org.au, Dr Harry Pritchard harry.pritchard@manchester.ac.uk and Dr Adam Greenstein adam.greenstein@manchester.ac.uk for further information.

Closing date:

Applications close: 15th August 2022

Please note:

Due to the volume of applications expected, only short-listed candidates may be contacted.

This is a Category A position according to the NSW Health Policy - Occupational Assessment, Screening Vaccination Against Specified Infectious Diseases. The successful applicant will be required to provide evidence of protection against the infectious diseases specified, at their own cost, prior to appointment

We support Equal Employment Opportunity. We value diversity and encourage applications from all people irrespective of race, religion, colour, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as an individual with a disability, or other applicable legally protected characteristic(s)

Apply now for: Postdoctoral Researcher - Microvascular Physiology

Your application should include: a cover letter and detailed CV, and the names and full contact details of three professional referees (including email addresses).

Postdoctoral Researcher - Atherosclerosis and Vascular Remodelling

An exciting opportunity exists to join a successful research group as part of a partnership between the Heart Research Institute, University of Sydney's Charles Perkins Centre and the Centre for Cardiovascular Science, Queen’s Medical Research Institute at the University of Edinburgh. This position provides a post-doctoral scientist an opportunity to contribute to leading atherosclerosis research through cardiovascular genetics. The scientist will investigate new molecular targets to be developed into novel treatment methods to prevent plaque rupture. Furthermore, there is a unique opportunity for the candidate to travel to the University of Edinburgh for single cell RNA-sequencing component of this project.

THE HEART RESEARCH INSTITUTE, located in Newtown, Sydney, is a centre of excellence in cardiovascular medical research and affiliated with the Royal Prince Alfred Hospital and the University of Sydney. Our research aims to understand the origins and mechanisms of cardiovascular diseases, including atherosclerosis and heart failure, and the contributions of diabetes and thrombosis.

THE CHARLES PERKINS CENTRE is facilitating world-class research; the translation of knowledge into practical solutions; the development of innovative, cross-disciplinary teaching programs to inspire the next generation of researchers; and forging new research partnerships within and beyond the University to enable the centres to deliver unique insights and results.

THE CENTRE FOR CARDIOVASCULAR SCIENCE is a world-leading centre of excellence that integrates discovery, translational and clinical cardiovascular research to transform the diagnosis, treatment and management of people with heart and circulatory diseases. We are working with local, national and international partners and funders to develop solutions to our research challenges with regional and global impact.

This partnership brings together the best minds from across the academic spectrum through cross-disciplinary collaboration to develop innovative approaches to alleviating the burden of cardiovascular disease (CVD).

For more information, visit the Heart Research Institute at https://hriuk.org, the Charles Perkins Centre at http://sydney.edu.au/perkins/ and Centre for Cardiovascular Science at https://www.ed.ac.uk/cardiovascular-science

Details:

The Heart Research Institute is seeking a post-doctoral scientist to contribute to innovative and collaborative research programs with a focus on cardiovascular genetic approaches to better understand the biology of the vasculature. The position would be within the Atherosclerosis and Vascular Remodelling group (AVRG) and Prof Andrew Baker’s lab at Centre for Cardiovascular Science at the University of Edinburgh. These groups are specialised in use of genetic lab models, lineage tracing, Cre-Lox conditional/tissue-specific knockouts, fluorescence activated cell sorting (FACS), single-cell RNA sequencing (scRNA-seq) and primary cell culture to elucidate mechanisms of CVD, and particularly atherosclerosis. In addition, these groups create new murine models to mimic vascular disease in humans to be used to assess progression of CVD, and to assess therapeutic targets that promote regression.

The postdoctoral scientist would also support other groups in HRI in collaborative projects that require expertise in genetic techniques.

Essential criteria – you will have:

  • United Kingdom citizenship (due to funding arrangements and planned collaboration opportunities, if selected you will be assisted in gaining appropriate visas and sponsorship to attain working rights in Australia)
  • A PhD in a biological field
  • Knowledge of cell biology
  • Experience in Cre-LoxP systems and mouse genetics
  • A knowledge of genomics approaches and molecular biology
  • A strong interest and commitment to translational research and producing high quality publications
  • High level of motivation and capacity for independent work
  • A track record of being team focused
  • Good interpersonal, written, and oral communication skills

Desirable criteria – you will have:

  • Experience in in vivo models of cardiovascular disease
  • Experience in models of immune/inflammatory disorders
  • Experience in animal surgery
  • Experience in in vitro cell culture and cell culture-based assays
  • Experience in small animal handling
  • Knowledge of confocal microscopy techniques
  • Experience in FACS and cell sorting

Position requirements:

In addition to the listed criteria, the successful candidate will be expected to contribute to the research program by performing a range of research-related tasks which may include the following:

  • Assist in the conduct and design of experiments
  • Assist in the general supervision of undergraduate and postgraduate students in the laboratory
  • Assist in the preparation of documents (for grant applications, research/conference papers, ethics applications)
  • Provide administrative and financial management support for research projects and programs including the maintenance of electronic databases and records
  • Maintain particular lab equipment and materials, including waste disposal and ordering supplies
  • Maintain occupational health and safety standards

The position is full time; flexible working arrangements may be negotiated. The appointment period is initially for 3 years with the possibility of renewal. You will be working on site at the Heart Research Institute and may also work at our premises at the Charles Perkins Centre located nearby at the University of Sydney when required.

A considerable component of this project will be guided by an experienced team at the Centre for Cardiovascular Science at the University of Edinburgh led by Prof Andrew Baker. The postdoctoral scientist will have the option of travelling to Edinburgh for several months to complete this part of the project.

Remuneration:

A competitive remuneration package along with salary-packaging options.

How to apply:

Your application should include:

  • a cover letter and detailed curriculum vitae (CV)
  • the names and full contact details of three professional referees (including email addresses)

Further information:

This can be obtained by contacting Dr Ashish Misra by email at ashish.misra@hri.org.au

Closing Date:

This job will close on the 4th of September 2022.

Please note:

Due to the volume of applications expected, only short-listed candidates may be contacted.

This is a Category A position according to the NSW Health Policy - Occupational Assessment, Screening Vaccination Against Specified Infectious Diseases. The successful applicant will be required to provide evidence of protection against the infectious diseases specified, at their own cost, prior to appointment.

The Heart Research Institute supports Equal Employment Opportunity. We value diversity and encourage applications from women, Aboriginal and Torres Strait Islanders, people with disability, LGBTQI individuals and applicants of diverse cultures and ages.

Apply now for: Postdoctoral Researcher - Atherosclerosis and Vascular Remodelling

Your application should include: a cover letter and detailed CV, and the names and full contact details of three professional referees (including email addresses).