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In addition to non-invasive imaging, we also aim to identify biomarkers of high-risk atherosclerotic plaque. Using state-of-the-art proteomics, metabolomics and lipidomics, this project characterises the molecular changes that distinguish stable from unstable atherosclerotic plaque in pre-clinical models, whether some of these characteristic molecular changes can be detected in blood of animals and, if so, how these findings extend to humans suffering from acute coronary syndrome or stroke. If successful, these studies may open the way for the development of novel biomarkers for and treatments of patients at elevated risk of a heart attack or stroke.