Project overview
Mitochondria are the powerhouses of our cells—and when they fail, things go badly wrong. The group has discovered that mitochondrial dysfunction plays a key role in damaging resistance arteries during septic shock, contributing to dangerously low blood pressure. Excitingly, our data suggest that restoring mitochondrial function could repair arteries and help stabilise blood pressure. In this project, we will use cutting-edge tools—including super-resolution microscopy, mass spectrometry, respirometry, and molecular biology—to uncover exactly how mitochondria become damaged. This research has the potential to reveal brand-new disease mechanisms and point the way to innovative treatments for septic shock.