OSA is a sleep disorder where breathing repeatedly stops and starts, causing intermittent episodes of hypoxia (low oxygen) and surges in brain activity.
These surges in brain activity cause elevations of blood pressure and blood glucose. The research team hypothesise that a progressive failure in a normally protective neurochemical signalling system may explain the chronic cardiometabolic changes in OSA, suggesting that it is the missing link between OSA, and diabetes and high blood pressure, and hence a novel therapeutic target.
The $25,000 grant to launch the project was awarded by the NSW Cardiovascular Research Network (CVRN) Near Miss Grants Program, which funds selected early to mid-career researchers in their cardiovascular disease research. The research team is spearheaded by Dr Farnham and pulls in the science and clinical expertise of Dr Kristina Cook (University of Sydney) and Dr Natasha Kumar (University of New South Wales), along with Prof Peter Cistulli (University of Sydney), Associate Professor John O’Sullivan (HRI) and Professor Roland Stocker (HRI).
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